Ruochen, Tianyi, and Dongyuan co-wrote this review article about the zero-inflation controversy in the single-cell RNA-seq field. In particular, we clarify statistical and biological concepts; introduce 5 mechanisms of adding non-biological zeros for fair method benchmarking; and compare 3 input data types: observed, imputed, and binarized counts. The work was published in Genome Biology. Here is the UCLA News. Congratulations!